Water for a 10 mg vial
No amount of water is the right one: the water sets the strength, and the strength sets the units each dose takes. 1 mL makes 10 mg per mL, 2 mL makes 5 mg per mL, 3 mL makes 3.33 mg per mL. Pick the water that puts your dose on a line of your syringe and keeps it within one syringe.
| Dose | with 1 mL10 mg/mL | with 2 mL5 mg/mL | with 3 mL3.33 mg/mL | Doses in the vial |
|---|---|---|---|---|
| 1 mg | 10 | 20 | 30 | 10 |
| 2 mg | 20 | 40 | 60 | 5 |
| 4 mg | 40 | 80 | over 100 | 2 |
| 8 mg | 80 | over 100 | over 100 | 1 |
| 12 mg | over 100 | over 100 | over 100 | less than 1 |
The doses are those of the retatrutide phase 2 trial, given once a week: arms of 1, 4, 8 and 12 mg, four of the six stepping up from 2 or 4 mg. The water changes the units per dose, not the number of doses: a 10 mg vial holds less than one 12 mg dose. The retatrutide dosage calculator lists the arms and their results.
Mixing the vial
- Find the water: read it from the table, or enter your dose and the units you want per dose above.
- Draw that much water into a syringe and inject it into the vial with the stream aimed at the glass wall, not at the powder.
- Swirl the vial gently until the powder has dissolved. Do not shake it.
- Write the concentration and the date mixed on the vial: Print label above prints the concentration with a line for the date.
Steps 2 and 3 are the handling the Serostim label gives for its freeze-dried somatropin; retatrutide has no FDA label. Sterile and bacteriostatic water are compared on the reconstitution calculator.
The example in the calculator. A 10 mg vial, a 2 mg dose, 40 units per dose. 40 units is 0.4 mL, so the mix must hold 2 mg in 0.4 mL: 5 mg per mL. 10 mg at 5 mg per mL is 2 mL of water, and the vial holds 5 doses of 2 mg.
Is retatrutide FDA-approved?
No. Retatrutide is an investigational drug in phase 3 trials, and the FDA has not approved it for any use.
- FDA
- Not approved, and cannot be used in compounding under federal law. FDA has warned companies selling it labelled “for research purposes” or “not for human consumption”.
- Advisory committee
- Not on the agenda of the Pharmacy Compounding Advisory Committee (meetings of October and December 2024 and July 2026), and not among the substances nominated for compounding under section 503A (FDA list updated 2026-05-14).
- WADA
- Not named on the 2026 Prohibited List or on the 2027 List. Its section S0 prohibits at all times any substance with no approval for human therapeutic use, such as drugs in clinical development.
- Trials
- Phase 3 (TRIUMPH): TRIUMPH-1 to TRIUMPH-4 completed, TRIUMPH-5 to TRIUMPH-9 active, not recruiting; no results posted on ClinicalTrials.gov.
Other calculators
- Retatrutide dosage calculatorUnits to draw for a retatrutide dose, from the mg in the vial and the water you added.
- How much bacteriostatic water for 30 mg retatrutideThe water to add to a 30 mg retatrutide vial so your dose is the number of units you want to draw.
- Peptide reconstitution calculatorThe water to add to the vial so your dose is the number of units you want to draw.
- Units to mg converterThe mg in the units you draw, or the units for an amount in mg, from the strength of your vial.
Questions
How much bac water for 10 mg of retatrutide?
As much as puts your dose on a line you can read. With 2 mL the vial is 5 mg per mL and the trial’s 2 mg step is 40 units; with 1 mL it is 10 mg per mL and 2 mg is 20 units; with 3 mL, 60 units.
How much does one unit hold?
With 1 mL of water, 0.1 mg (100 mcg); with 2 mL, 0.05 mg (50 mcg); with 3 mL, 0.033 mg (33.3 mcg). A unit is 0.01 mL on a U-100 syringe.
How many doses are in a 10 mg vial?
10 doses of 1 mg, 5 of 2 mg, 2 of 4 mg and 1 of 8 mg, whatever the water. A 12 mg dose needs more than one 10 mg vial.
Is retatrutide FDA-approved?
No. As of 2026-10-01 the FDA says it is not a component of any FDA-approved drug and cannot be used in compounding under federal law.
Sources
- Jastreboff AM et al. Triple-hormone-receptor agonist retatrutide for obesity: a phase 2 trialN Engl J Med 2023;389:514–526, PubMed 37366315. Abstract: the dose arms and the 2 mg starting dose.
- NCT04881760: phase 2 study of LY3437943 in obesity or overweightClinicalTrials.gov, record retrieved 2026-10-28. Arms and interventions: the steps of each arm.
- FDA’s concerns with unapproved GLP-1 drugs used for weight lossFDA, content current as of 2026-10-01. Retatrutide cannot be used in compounding; warnings to sellers.
- Serostim (somatropin) for injection, prescribing informationFDA, label of 2026-07-29. 2.2 Preparation and Administration: the stream against the vial wall, swirl and do not shake.
- WADA Prohibited List 2026In effect 2026-01-01. S0, non-approved substances.
- BD Insulin Syringe, 510(k) K190054FDA, cleared 2019-10-21. U-100 syringes of 0.3, 0.5 and 1 mL and their lines.